Unexpected Diversity of Cellular Immune Responses against Nef and Vif in HIV-1-Infected Patients Who Spontaneously Control Viral Replication
Identifieur interne : 002604 ( Main/Exploration ); précédent : 002603; suivant : 002605Unexpected Diversity of Cellular Immune Responses against Nef and Vif in HIV-1-Infected Patients Who Spontaneously Control Viral Replication
Auteurs : Leandro F. Tarosso [Brésil] ; Mariana M. Sauer [Brésil] ; Sabri Sanabani [Brésil] ; Maria Teresa Giret [Brésil] ; Helena I. Tomiyama [Brésil] ; John Sidney [États-Unis] ; Shari M. Piaskowski [États-Unis] ; Ricardo S. Diaz [Brésil] ; Ester C. Sabino [Brésil] ; Alessandro Sette [États-Unis] ; Jorge Kalil-Filho [Brésil] ; David I. Watkins [États-Unis] ; Esper G. Kallas [Brésil]Source :
- PLoS ONE [ 1932-6203 ] ; 2010.
Descripteurs français
- KwdFr :
- Antigènes HLA-B (génétique), Fonctions de vraisemblance, Génome viral (génétique), Immunité cellulaire (génétique), Immunité cellulaire (immunologie), Infections à VIH (immunologie), Infections à VIH (virologie), Lymphocytes T CD4+, Phylogénie, Produits du gène nef du virus de l'immunodéficience humaine (immunologie), Produits du gène vif du virus de l'immunodéficience humaine (immunologie), Réaction de polymérisation en chaîne, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), Variation génétique (génétique), Épitopes (génétique), Épitopes (immunologie), Études de cohortes.
- MESH :
- génétique : Antigènes HLA-B, Génome viral, Immunité cellulaire, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Variation génétique, Épitopes.
- immunologie : Immunité cellulaire, Infections à VIH, Produits du gène nef du virus de l'immunodéficience humaine, Produits du gène vif du virus de l'immunodéficience humaine, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Épitopes.
- virologie : Infections à VIH.
- Fonctions de vraisemblance, Lymphocytes T CD4+, Phylogénie, Réaction de polymérisation en chaîne, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Études de cohortes.
English descriptors
- KwdEn :
- CD4-Positive T-Lymphocytes, Cohort Studies, Epitopes (genetics), Epitopes (immunology), Genetic Variation (genetics), Genome, Viral (genetics), HIV Infections (immunology), HIV Infections (virology), HIV-1 (classification), HIV-1 (genetics), HIV-1 (immunology), HLA-B Antigens (genetics), Immunity, Cellular (genetics), Immunity, Cellular (immunology), Likelihood Functions, Phylogeny, Polymerase Chain Reaction, nef Gene Products, Human Immunodeficiency Virus (immunology), vif Gene Products, Human Immunodeficiency Virus (immunology).
- MESH :
- chemical , genetics : Epitopes, HLA-B Antigens.
- chemical , immunology : Epitopes, nef Gene Products, Human Immunodeficiency Virus, vif Gene Products, Human Immunodeficiency Virus.
- classification : HIV-1.
- genetics : Genetic Variation, Genome, Viral, HIV-1, Immunity, Cellular.
- immunology : HIV Infections, HIV-1, Immunity, Cellular.
- virology : HIV Infections.
- CD4-Positive T-Lymphocytes, Cohort Studies, Likelihood Functions, Phylogeny, Polymerase Chain Reaction.
Abstract
HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus.
Here we compared cellular immune responses against
This suggests that the cellular immune responses against HIV-1 in controller patients may be broader than we had previously anticipated.
Url:
DOI: 10.1371/journal.pone.0011436
PubMed: 20625436
PubMed Central: 2896403
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>Cohort Studies</term>
<term>Epitopes (genetics)</term>
<term>Epitopes (immunology)</term>
<term>Genetic Variation (genetics)</term>
<term>Genome, Viral (genetics)</term>
<term>HIV Infections (immunology)</term>
<term>HIV Infections (virology)</term>
<term>HIV-1 (classification)</term>
<term>HIV-1 (genetics)</term>
<term>HIV-1 (immunology)</term>
<term>HLA-B Antigens (genetics)</term>
<term>Immunity, Cellular (genetics)</term>
<term>Immunity, Cellular (immunology)</term>
<term>Likelihood Functions</term>
<term>Phylogeny</term>
<term>Polymerase Chain Reaction</term>
<term>nef Gene Products, Human Immunodeficiency Virus (immunology)</term>
<term>vif Gene Products, Human Immunodeficiency Virus (immunology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Antigènes HLA-B (génétique)</term>
<term>Fonctions de vraisemblance</term>
<term>Génome viral (génétique)</term>
<term>Immunité cellulaire (génétique)</term>
<term>Immunité cellulaire (immunologie)</term>
<term>Infections à VIH (immunologie)</term>
<term>Infections à VIH (virologie)</term>
<term>Lymphocytes T CD4+</term>
<term>Phylogénie</term>
<term>Produits du gène nef du virus de l'immunodéficience humaine (immunologie)</term>
<term>Produits du gène vif du virus de l'immunodéficience humaine (immunologie)</term>
<term>Réaction de polymérisation en chaîne</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term>
<term>Variation génétique (génétique)</term>
<term>Épitopes (génétique)</term>
<term>Épitopes (immunologie)</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Epitopes</term>
<term>HLA-B Antigens</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Epitopes</term>
<term>nef Gene Products, Human Immunodeficiency Virus</term>
<term>vif Gene Products, Human Immunodeficiency Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>HIV-1</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Variation</term>
<term>Genome, Viral</term>
<term>HIV-1</term>
<term>Immunity, Cellular</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA-B</term>
<term>Génome viral</term>
<term>Immunité cellulaire</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
<term>Variation génétique</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunité cellulaire</term>
<term>Infections à VIH</term>
<term>Produits du gène nef du virus de l'immunodéficience humaine</term>
<term>Produits du gène vif du virus de l'immunodéficience humaine</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV Infections</term>
<term>HIV-1</term>
<term>Immunity, Cellular</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term>
<term>Cohort Studies</term>
<term>Likelihood Functions</term>
<term>Phylogeny</term>
<term>Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Fonctions de vraisemblance</term>
<term>Lymphocytes T CD4+</term>
<term>Phylogénie</term>
<term>Réaction de polymérisation en chaîne</term>
<term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term>
<term>Études de cohortes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>HIV-1-infected individuals who spontaneously control viral replication represent an example of successful containment of the AIDS virus. Understanding the anti-viral immune responses in these individuals may help in vaccine design. However, immune responses against HIV-1 are normally analyzed using HIV-1 consensus B 15-mers that overlap by 11 amino acids. Unfortunately, this method may underestimate the real breadth of the cellular immune responses against the autologous sequence of the infecting virus.</p>
</sec>
<sec><title>Methodology and Principal Findings</title>
<p>Here we compared cellular immune responses against <italic>nef</italic>
and <italic>vif</italic>
-encoded consensus B 15-mer peptides to responses against HLA class I-predicted minimal optimal epitopes from consensus B and autologous sequences in six patients who have controlled HIV-1 replication. Interestingly, our analysis revealed that three of our patients had broader cellular immune responses against HLA class I-predicted minimal optimal epitopes from either autologous viruses or from the HIV-1 consensus B sequence, when compared to responses against the 15-mer HIV-1 type B consensus peptides.</p>
</sec>
<sec><title>Conclusion and Significance</title>
<p>This suggests that the cellular immune responses against HIV-1 in controller patients may be broader than we had previously anticipated.</p>
</sec>
</div>
</front>
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<author><name sortKey="Walker, Bd" uniqKey="Walker B">BD Walker</name>
</author>
</analytic>
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<author><name sortKey="Addo, Mm" uniqKey="Addo M">MM Addo</name>
</author>
<author><name sortKey="Kaufmann, De" uniqKey="Kaufmann D">DE Kaufmann</name>
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</author>
<author><name sortKey="Miura, T" uniqKey="Miura T">T Miura</name>
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<biblStruct><analytic><author><name sortKey="Garcia, Pm" uniqKey="Garcia P">PM Garcia</name>
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<author><name sortKey="Kalish, La" uniqKey="Kalish L">LA Kalish</name>
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<author><name sortKey="Quinn, Tc" uniqKey="Quinn T">TC Quinn</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wawer, Mj" uniqKey="Wawer M">MJ Wawer</name>
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<author><name sortKey="Gray, Rh" uniqKey="Gray R">RH Gray</name>
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<author><name sortKey="Sewankambo, Nk" uniqKey="Sewankambo N">NK Sewankambo</name>
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<author><name sortKey="Serwadda, D" uniqKey="Serwadda D">D Serwadda</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Walker, Bd" uniqKey="Walker B">BD Walker</name>
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<biblStruct><analytic><author><name sortKey="Bailey, Jr" uniqKey="Bailey J">JR Bailey</name>
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<author><name sortKey="Williams, Tm" uniqKey="Williams T">TM Williams</name>
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<author><name sortKey="Blankson, Jn" uniqKey="Blankson J">JN Blankson</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Chowdhury, Ih" uniqKey="Chowdhury I">IH Chowdhury</name>
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<author><name sortKey="Dorfman, T" uniqKey="Dorfman T">T Dorfman</name>
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</biblStruct>
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<author><name sortKey="Klein, Kc" uniqKey="Klein K">KC Klein</name>
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<biblStruct><analytic><author><name sortKey="Sova, P" uniqKey="Sova P">P Sova</name>
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</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Brésil</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Wisconsin</li>
<li>État de São Paulo</li>
</region>
<settlement><li>São Paulo</li>
</settlement>
<orgName><li>Université de São Paulo</li>
</orgName>
</list>
<tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Tarosso, Leandro F" sort="Tarosso, Leandro F" uniqKey="Tarosso L" first="Leandro F." last="Tarosso">Leandro F. Tarosso</name>
</region>
<name sortKey="Diaz, Ricardo S" sort="Diaz, Ricardo S" uniqKey="Diaz R" first="Ricardo S." last="Diaz">Ricardo S. Diaz</name>
<name sortKey="Giret, Maria Teresa" sort="Giret, Maria Teresa" uniqKey="Giret M" first="Maria Teresa" last="Giret">Maria Teresa Giret</name>
<name sortKey="Kalil Filho, Jorge" sort="Kalil Filho, Jorge" uniqKey="Kalil Filho J" first="Jorge" last="Kalil-Filho">Jorge Kalil-Filho</name>
<name sortKey="Kallas, Esper G" sort="Kallas, Esper G" uniqKey="Kallas E" first="Esper G." last="Kallas">Esper G. Kallas</name>
<name sortKey="Kallas, Esper G" sort="Kallas, Esper G" uniqKey="Kallas E" first="Esper G." last="Kallas">Esper G. Kallas</name>
<name sortKey="Sabino, Ester C" sort="Sabino, Ester C" uniqKey="Sabino E" first="Ester C." last="Sabino">Ester C. Sabino</name>
<name sortKey="Sanabani, Sabri" sort="Sanabani, Sabri" uniqKey="Sanabani S" first="Sabri" last="Sanabani">Sabri Sanabani</name>
<name sortKey="Sauer, Mariana M" sort="Sauer, Mariana M" uniqKey="Sauer M" first="Mariana M." last="Sauer">Mariana M. Sauer</name>
<name sortKey="Tomiyama, Helena I" sort="Tomiyama, Helena I" uniqKey="Tomiyama H" first="Helena I." last="Tomiyama">Helena I. Tomiyama</name>
</country>
<country name="États-Unis"><region name="Californie"><name sortKey="Sidney, John" sort="Sidney, John" uniqKey="Sidney J" first="John" last="Sidney">John Sidney</name>
</region>
<name sortKey="Piaskowski, Shari M" sort="Piaskowski, Shari M" uniqKey="Piaskowski S" first="Shari M." last="Piaskowski">Shari M. Piaskowski</name>
<name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name>
<name sortKey="Watkins, David I" sort="Watkins, David I" uniqKey="Watkins D" first="David I." last="Watkins">David I. Watkins</name>
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</tree>
</affiliations>
</record>
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